Python provides a pretty handy module for performin MD5 sums of both text and data buffers. The following function provides an MD5 sum given a file name:
def get_hash(self, filename):
"""
Generates an md5 sum of a file
"""
f = file(filename,'rb');
m = md5.new();
readBytes = 1024; # read 1024 bytes per time
totalBytes = 0;
while (readBytes):
readString = f.read(readBytes);
m.update(readString);
readBytes = len(readString);
totalBytes+=readBytes;
f.close();
return m.hexdigest();